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The Royal Society of Chemistry is partnering with InnoCentive to provide you with an opportunity to tackle a variety of scientific and non-technical problems.

We recently launched our Open Innovation Pavilion on InnoCentive.com which features InnoCentive-customer Challenges that seek innovative solutions.

Do you have a possible solution to one of the Challenges below?

Anyone can submit solutions, with cash awards on offer for the winning Solvers. Click on the links below to unlock new routes to collaboration and to help address some of the greatest Challenges facing our world today.

Featured Challenges:

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Preventing Migration of a Small Molecule Through a Film

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AWARD: $15,000 USD
DEADLINE: 10/09/216

The Seeker is looking to prevent the migration of an amine through a film under harsher than normal conditions (e.g. high temperature). Solutions could take the form of a film change/treatment, a substitute for the amine or anything else that could prevent migration without losing qualities of the product.

This Theoretical Challenge requires only a written proposal.

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Alternatives to Live Vaccines

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AWARD: $20,000 USD
DEADLINE: 10/31/16

Vaccination is a safe and effective way of gaining protection from preventable diseases. In order to elicit a natural immune response, some vaccines are prepared with live organisms. However, live vaccines are not recommended when the immune system is weakened or compromised. Therefore, the Seeker is searching for viable alternatives to live vaccines.

This Theoretical Challenge requires only a written proposal.

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The SUDEP Institute Challenge: Developing Predictive Biomarkers of Epilepsy Seizures

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AWARD: $1,000,000
DEADLINE: 10/10/20

Nearly 3 million people in the United States and 65 million people worldwide have epilepsy, a neurological condition which affects the nervous system and causes seizures. Among those living with epilepsy, nearly one-third have ongoing seizures despite existing therapies. Each year, more than 1 out of 1,000 people with epilepsy die from sudden unexpected death in epilepsy (SUDEP). If seizures are uncontrolled, the risk of SUDEP increases to more than 1 out of 150. SUDEP is the leading cause of death in young adults with uncontrolled seizures.

In order to accelerate the identification of effective treatments for SUDEP, the Epilepsy Foundation SUDEP Institute is sponsoring a Reduction to Practice Challenge to develop a predictive biomarker or panel of biomarkers to identify people at risk for SUDEP or seizures that compromise cardiac or respiratory function. The biomarker(s) must serve as an endpoint or surrogate endpoint that will drive human SUDEP interventions. For example, the biomarker(s) may identify a high risk patient group that could be used to test existing candidate interventions such as seizure detection devices.

This is a Reduction to Practice Challenge that requires written documentation, experimental proof-of-concept data, and biomarker validation data.

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AstraZeneca Challenge: In Vitro System to Assess Gastrointestinal Toxicity

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AWARD: $25,000
DEADLINE: 2/21/17

The gastrointestinal (GI) tract is the system of organs by which food is ingested and digested, nutrients are absorbed, and waste products are eliminated. GI cell proliferation is essential for maintaining normal physiological function and integrity of the protective epithelial barrier, however, as many GI cells turn over at a rapid rate, normal function and barrier maintenance are highly sensitive to toxic insults. When drug-induced GI toxicity occurs, either by cytotoxicity, inhibition of cell proliferation, or adverse pharmacological effect on receptors and enzymes, damage manifests with a variety of clinical symptoms including nausea, vomiting, ulceration, and diarrhea. It is essential to understand and minimize these consequences, thus AstraZeneca seeks a translationally relevant in vitro model to investigate gastrointestinal toxicity onset and recovery.

This is a Reduction-to-Practice Challenge that requires written documentation, experimental proof-of-concept data, and validation results.

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Prevention and Control of Mastitis in Cattle

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AWARD: $30,000
DEADLINE: 10/23/16

Bovine mastitis, an inflammation of the mammary gland due to pathogen invasion, continues to be a main concern in the global dairy industry. Mastitis is the main reason dairy cows are administered antibiotics, and the antibiotics utilized for mastitis treatment and prevention tend to be classified as medically important. In an effort to develop antibiotic alternatives and decrease the amount of antibiotics used for mastitis therapy, Elanco desires a novel solution to prevent, treat, or control mastitis in cattle.

This Theoretical Challenge requires only a written proposal.

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Prevention and Control of Streptococcus suis Infections in Swine

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AWARD: $30,000
DEADLINE: 10/23/16

Streptococcus suis is not only a pathogenic bacterium that impacts swine production, but it also is a zoonotic agent responsible for an increasing number of human infections in recent years. Preventative treatment of swine herds with vaccines has resulted in relatively low levels of protection. Pigs may also be administered antibiotics, usually of a medically important class, to control infection. Despite the effectiveness of antibiotics for disease prevention, there is pressure to reduce use of these agents in pig farming. Therefore, Elanco desires novel approaches to prevent, treat, or control S. suis infection in swine

This Theoretical Challenge requires only a written proposal.

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